Which of the following vaccines is not typically refrigerated?

The COVID-19 vaccines are unique in their storage requirements compared to many other vaccines, as some of them do not require refrigeration, enabling them to be stored at higher temperatures for certain durations. For example, the Johnson & Johnson vaccine can be stored in a standard refrigerator, while the Pfizer-BioNTech vaccine initially required ultra-cold storage but has been adapted for standard refrigeration in specific circumstances.

In contrast, DTaP, MMR, and the shingles vaccine are typically stored under refrigeration due to their stability and effectiveness at those temperatures. Vaccines like DTaP and MMR must be kept at 2°C to 8°C (35°F to 46°F) to ensure they remain viable, as exposure to higher temperatures could compromise their efficacy. The shingles vaccine also requires refrigeration to maintain its effectiveness.

Thus, the distinction of the COVID-19 vaccines regarding refrigeration stands out, making that choice the correct answer.